Women's Health Weekly
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Breast Cancer
Research in the area of breast cancer reported from Lund University
May 15th, 2008
According to a study from Lund, Sweden, "Polyamine analogues are presently undergoing clinical evaluation in the treatment of cancer. To better understand under what circumstances treatment with a polyamine analogue will yield beneficial results, we have investigated the effect of N-1,N-11-diethylnorspermine (DENSPM) on cell cycle kinetics of the human breast cancer cell lines SK-BR-3, MCF-7, HCC1937, and L56Br-C1." "A bromodeoxyuridine-DNA flow cytometry method was used to evaluate the treatment with 10 mu mol/l DENSPM on cell cycle kinetics. A correlation between polyamine pool size after DENSPM treatment and cell cycle kinetic effects was found. The most sensitive...
Source: Women's Health Weekly (2008-05-15)
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