Women's Health Weekly
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Breast Cancer
Research on breast cancer detailed by scientists at Vanderbilt University
May 15th, 2008
"The mitochondrial DNA (mtDNA) 4977-bp deletion (Delta mtDNA(4977) mutation) is one of the most frequently observed mtDNA mutations in human tissues and may play a role in carcinogenesis. Only a few studies have evaluated Delta mtDNA(4977) mutation in breast cancer tissue, and the findings have been inconsistent, which may be due to methodological differences," investigators in the United States report. "In this study, we developed a quantitative real-time PCR assay to assess the level of the Delta mtDNA(4977) mutation in tumor tissue samples from 55 primary breast cancer patients and 21 patients with benign breast disease (BBD). The Delta mtDNA(4977) mutation was...
Source: Women's Health Weekly (2008-05-15)
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