Women's Health Weekly
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Breast Cancer
Research on breast cancer published by C. Dang et al
May 15th, 2008
According to a study from the United States, " Dose-dense (dd) doxorubicin and cyclophosphamide (AC) followed by paclitaxel (P) is superior to every 3-weekly AC followed by P. Given the demonstrated cardiac safety for trastuzuamb (T) with conventionally scheduled AC followed by P, we tested the safety of dd AC followed by P with T. The primary end point was cardiac safety, and the secondary end points were time to recurrence and overall survival. Patients with HER-2/neu immunohistochemistry (IHC) 3+ or fluorescent in situ hybridization (FISH)-amplified breast cancer and baseline left ventricular ejection fraction (LVEF) of >= 55% were enrolled, regardless of tumor size or nodal...
Source: Women's Health Weekly (2008-05-15)
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