Women's Health Weekly
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Breast Cancer
Research reports on breast cancer from B. Frank and colleagues provide new insights
May 15th, 2008
According to recent research from Heidelberg, Germany, "Data from several studies have suggested that polymorphisms in A-kinase anchoring proteins (AKAPs), which are key components of signal transduction, contribute to carcinogenesis. To evaluate the impact of AKAP variants on breast cancer risk, we genotyped six nonsynonymous sing le-nucleotide polymorphisms that were predicted to be deleterious and found two (M4631, 1389G >T and N2792S, 8375A >G) to be associated with an allele dose-dependent increase in risk of familial breast cancer in a German population." "We extended the analysis of AKAP9 M4631, which is in strong linkage disequilibrium with AKAP9 N2792S,...
Source: Women's Health Weekly (2008-05-15)
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