Women's Health Weekly
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Breast Cancer
Data on breast cancer detailed by researchers at Montreal General Hospital
May 15th, 2008
"About 40% of French Canadian breast and/or ovarian cancer families harbor germline BRCA1 or BRCA1 mutations where common mutations account for about 84% of all mutations identified in cancer families. Within a series of BRCA1 and BRCA2 mutation-negative families, a germline TP53 13398 G> A (Arg213Gln) mutation was identified, which was selected for mutation analysis in this gene because of a family history consistent with Li-Fraumeni syndrome (LFS)," researchers in Montreal, Canada report. "Given the founder effects in this population, the 13398 G> A mutation was screened in series of 52 BRCA1 and BRCA2 mutation-negative cancer families, and a mutation-positive...
Source: Women's Health Weekly (2008-05-15)
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