Women's Health Weekly
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Breast Cancer
New breast cancer research has been reported by scientists at University of Kentucky
May 22nd, 2008
According to a study from the United States, "The breast cancer resistance protein ( BCRP; ABCG2) is an ATP-dependent efflux multidrug transporter that belongs to the G family of half-transporters that consist of six transmembrane-spanning domains and must homodimerize to form the active membrane transporter. It is expressed in the apical plasma membrane domain of the small intestine, endothelium, and liver, where it has been shown to play an important role in limiting drug absorption and distribution and in enhancing drug clearance, respectively." "BCRP is also expressed in the apical membrane of mammary alveolar epithelia, where it mediates efflux of substrates into...
Source: Women's Health Weekly (2008-05-22)
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