Women's Health Weekly
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Breast Cancer
New findings reported from University of North Carolina describe advances in breast cancer
May 22nd, 2008
"DNA hypermethylation events and other epimutations occur in many neoplasms, producing gene expression changes that contribute to neoplastic transformation, tumorigenesis, and tumor behavior. Some human cancers exhibit a hypermethylator phenotype, characterized by concurrent DNA methylation-dependent silencing of multiple genes," scientists writing in the journal Molecular Cancer report. "To determine if a hypermethylation defect occurs in breast cancer, the expression profile and promoter methylation status of methylation-sensitive genes were evaluated among breast cancer cell lines. The relationship between gene expression (assessed by RT-PCR and quantitative...
Source: Women's Health Weekly (2008-05-22)
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