Women's Health Weekly
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Breast Cancer
Reports summarize breast cancer research from V. Gouazeandersson and co-authors
May 22nd, 2008
"In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Acute exposure (72 h) to C8-ceramide (5 mu g/ml culture medium), a cell-permeable ceramide, increased MDR1 mRNA levels by 3- and 5-fold in T47D and in MDA-MB-435 cells, respectively," researchers in the United States report. "Acute exposure of MCF-7 and MDA-MB-231 cells to C8-GC (10 mu g/ml culture medium), a cell-permeable analog of GC, increased MDR1 expression by 2- and 4- fold, respectively. Chronic...
Source: Women's Health Weekly (2008-05-22)
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