Women's Health Weekly
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Breast Cancer
Study results from S.J. Kuo et al provide new insights into breast cancer
May 22nd, 2008
According to recent research from Changhua, Taiwan, "Expression of thymidylate synthase (TS) in tumor cells is frequently suggested as an important prognostic factor for patients scheduled for chemotherapy with 5-fluorouracil (5-FU). However, clinical evidence does not fully support such an anticipation." "We studied the expression of rTS beta, a reverse orientation gene of TS, as a 5-FU resistance marker in patients with primary breast cancer. Expression of rTS beta was examined in 129 patients with newly diagnosed breast cancer and five breast cancer cell lines by immunohistochemistry, immunocytochemistry and immunoblotting. Clinically, expression of rTS beta was found to...
Source: Women's Health Weekly (2008-05-22)
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