Women's Health Weekly
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Cancer
Study data from University of Washington provide new insights into cancer
May 22nd, 2008
According to a study from the United States, "Breast cancer resistance protein (BCRP) is most abundantly expressed in the apical membrane of placental syncytiotrophoblasts, suggesting that it may protect the fetus by impeding drug penetration across the placental barrier. Glyburide (GLB) is an antidiabetic drug routinely used to treat gestational diabetes." "In this study, we first determined whether GLB is a BCRP/Bcrp1 substrate. The intracellular [H-3]GLB concentrations in Madin-Darby canine kidney (MDCK)/BCRP cells were significantly lower than those in MDCK/vector cells. The addition of 10 mc M fumitremorgin C, a specific BCRP inhibitor, significantly increased the...
Source: Women's Health Weekly (2008-05-22)
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