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Emory University

Previously unseen switch regulates breast cancer response to estrogen

Published in Women's Health Weekly, May 22nd, 2008

A tiny modification called methylation on estrogen receptors prolongs the life of these growth-driving molecules in breast cancer cells, according to research by scientists at Emory University's Winship Cancer Institute.

The results are published in the May 9, 2008 issue of the journal Molecular Cell.

Most breast cancers contain estrogen receptors, which enable them to grow in the presence of the hormone estrogen. Their presence can determine whether tumors will respond to the estrogen-blocking drug tamoxifen.

The finding will help researchers sort out how mutations change the estrogen receptor's function and allow some breast...

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