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Women's Health Weekly

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Breast Cancer



Findings from Michigan State University advance knowledge in breast cancer



May 29th, 2008

According to recent research published in the Biochemical Journal, "Accumulating evidence indicates that heregulins, EGF (epidermal growth factor)-like ligands, promote breast cancer cell proliferation and are involved in the progression of breast cancer towards an aggressive and invasive phenotype. However, there is limited information regarding the molecular mechanisms that mediate these effects."

"We have recently established that HRG (heregulin 1) promotes breast cancer cell proliferation and migration via cross-talk with EGFR (EGF receptor) that involves the activation of the small GTPase Rac1. In the present paper we report that Rac1 is an essential player...


Source: Women's Health Weekly (2008-05-29)

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