Women's Health Weekly
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Breast Cancer
Reports from University of Notre Dame describe recent advances in breast cancer
May 29th, 2008
According to a study from the United States, "Since the discovery of the vitamin D receptor (VDR) in mammary cells, the role of the vitamin D signaling pathway in normal glandular function and in breast cancer has been extensively explored. In vitro studies have shown that the VDR ligand, 1,25-dihydroxyvitamin D (1,25D), modulates key proteins involved in signaling proliferation, differentiation, and survival of normal mammary epithelial cells." "Similar antiproliferative and pro-differentiating effects of 1,25D have been observed in VDR-positive breast cancer cells, indicating that transformation per se does not abolish vitamin D signaling. However, many transformed...
Source: Women's Health Weekly (2008-05-29)
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