Women's Health Weekly
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Breast Cancer
Studies from Medical University of South Carolina have provided new information about breast cancer
May 29th, 2008
According to recent research published in the journal Cancer Research, "sought to determine whether nucleolin, a bcl-2 mRNA-binding protein, has a role in the regulation of bcl-2 mRNA stability in MCF-7 and MDA-MB-231 breast cancer cells. Furthermore, we examined the efficacy of the aptamer AS1411 in targeting nucleolin and inducing bcl-2 mRNA instability and cytotoxicity in these cells." "AS1411 at 5 mu mol/L inhibited the growth of MCF-7 and MDA-MB-231 cells, whereas 20 mu mol/L AS1411 had no effect on the growth rate or viability of normal MCF-10A mammary epithelial cells. This selectivity of AS1411 was related to a greater uptake of AS1411 into the cytoplasm...
Source: Women's Health Weekly (2008-05-29)
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