Women's Health Weekly
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Breast Cancer
Study data from Technical University of Dresden update understanding of breast cancer
May 29th, 2008
According to recent research from Dresden, Germany, "Estrogen regulates various cytokines and growth factors in estrogen receptor (ER)-positive human breast cancer. Receptor activator of NF-kappa B ligand (RANKL) is an essential cytokine for osteoclasts, whereas osteoprotegerin (OPG) is a soluble inhibitor for RANKL." "We analyzed the regulation of the RANKL/OPG system by estrogens and androgens in the ER-positive breast cancer cell line MCF-7 and the ER-negative breast cancer cell line MDA-MB-231. In MCF-7 cells, which predominantly express ER-alpha, 17 beta-estradiol and testosterone dose-dependently decreased OPG mRNA levels and protein secretion by 70 and 65%,...
Source: Women's Health Weekly (2008-05-29)
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