Women's Health Weekly
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Breast Cancer
New breast cancer research from University Hospital outlined
June 5th, 2008
According to recent research from Parma, Italy, " The anti-HER-2/neu monoclonal antibody trastuzumab has been shown to engage both activatory (fragment C receptor [Fc gamma R]IIIa; Fc gamma RIIa) and inhibitory (Fc gamma RIIb) antibody receptors and Fc gamma R polymorphisms have been identified that may affect the antibody-dependent cell-mediated cytotoxicity (ADCC) of natural-killer cells/monocytes. In this study, we tested whether Fc gamma R polymorphisms are associated with clinical outcome of patients with breast cancer who received trastuzumab." "Patients and Methods Fifty-four consecutive patients with HER-2/neu-amplified breast cancer receiving trastuzumab plus...
Source: Women's Health Weekly (2008-06-05)
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