Women's Health Weekly
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Breast Cancer
Recent findings from S.W. Chan and co-authors highlight research in breast cancer
June 5th, 2008
According to recent research from Singapore, Singapore, "TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, modulates mesenchymal stem cell differentiation. We now show that TAZ plays a critical role in the migration, invasion, and tumorigenesis of breast cancer cells." "TAZ is conspicuously expressed in human breast cancer cell lines in which its expression levels generally correlate with the invasiveness of cancer cells. Overexpression of TAZ in low-expressing MCF10A cells causes morphologic changes characteristic of cell transformation and promotes cell migration and invasion. Conversely, RNA interference-mediated knockdown of TAZ...
Source: Women's Health Weekly (2008-06-05)
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