Women's Health Weekly
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Breast Cancer
Research from University of Michigan, Medical Department provides new data on breast cancer
June 5th, 2008
"Estrogen signaling plays an essential role in breast cancer progression, and estrogen receptor (ER) status has long been a marker of hormone responsiveness. However, ER status alone has been an incomplete predictor of endocrine therapy, as some ER+ tumors, nevertheless, have poor prognosis," scientists in the United States report. "Here we sought to use expression profiling of ER+ breast cancer cells to screen for a robust estrogen-regulated gene signature that may serve as a better indicator of cancer outcome. We identified 532 estrogen-induced genes and further developed a 73-gene signature that best separated a training set of 286 primary breast carcinomas into...
Source: Women's Health Weekly (2008-06-05)
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