Women's Health Weekly
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Breast Cancer
Research on breast cancer discussed by scientists at Northwestern University
June 5th, 2008
"A role for prolactin (PRL) in the pathogenesis of breast cancer has been confirmed at the cellular level in vitro, with multiple transgenic and knockout models in vivo, and within sizable patient populations through epidemiologic analysis. It is the obvious ''next step'' that these findings are translated into meaningful therapies to block PRL/PRLr function in human breast cancer," investigators in the United States report. "Several broad categories of PRL/PRLr antagonists are discussed in their pre-clinical context, including inhibitors of endocrine PRL elaboration, mutant ligand antagonists, ligand chimeras, and inhibitors of PRL-induced signaling and...
Source: Women's Health Weekly (2008-06-05)
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