Women's Health Weekly
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Cancer
Reports from University of Southampton advance knowledge in cancer
June 12th, 2008
"Regulation of the synthesis, function and degradation of HDM2 (Mdm2 in mouse) plays a key role in controlling the abundance and activity of the transcription factor p53, with consequent implications for the proliferation and survival of normal and cancer cells. We have previously identified the regulation of export of HDM2 mRNA from the nucleus as a novel point of control of HDM2 synthesis," scientists in Southampton, the United Kingdom report. "This process is dependent on the activity of the growth factor-regulated MAP-kinase kinases ( MEKs). Here, we provide evidence that the eIF4E kinase MNK1 is a key downstream effector of MEKs in this regulatory pathway. We show...
Source: Women's Health Weekly (2008-06-12)
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