Women's Health Weekly
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Carcinogenesis
Findings from University of Karlsruhe provide new insights into carcinogenesis
June 12th, 2008
According to a study from Karlsruhe, Germany, "The tissue concentrations of the female sex hormone 17 beta-estradiol (E2) and its reactive catechol metabolites such as 4-hydroxyestradiol (4-HO-E2) play important roles in hormonal carcinogenesis. They are influenced by the activity of local enzymes involved in the metabolic activation and inactivation of E2." "In the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase (COMT). Food supplements containing the soy isoflavones genistein and daidzein are consumed because they are believed to protect from breast cancer; however, this proposed benefit is controversial. The aim of the...
Source: Women's Health Weekly (2008-06-12)
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