Women's Health Weekly
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Breast Cancer
Researchers from Children's Hospital detail new studies and findings in the area of breast cancer
June 19th, 2008
According to a study from the United States, "The hypothesis was tested that sequence diversity in breast cancer resistance protein ( BCRP)'s cis-regulatory region is a significant determinant of BCRP expression. The BCRP promoter and intron 1 were resequenced in lymphoblast DNA from the polymorphism discovery resource (PDR) 44 subset." "BCRP single nucleotide polymorphisms ( SNPs) were genotyped in donor human livers, intestines, and lymphoblasts quantitatively phenotyped for BCRP mRNA expression. Carriers of the -15622C > T SNP had lower BCRP expression in multiple tissues. The intron 1 SNP 16702C > T was associated with high expression in livers; 1143G > A...
Source: Women's Health Weekly (2008-06-19)
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