Women's Health Weekly
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Breast Cancer
Scientists at University of Wisconsin discuss research in breast cancer
June 19th, 2008
"Invasive cancer cells form dynamic adhesive structures associated with matrix degradation called invadopodia. Calpain 2 is a calcium-dependent intracellular protease that regulates adhesion turnover and disassembly through the targeting of specific substrates such as talin," scientists writing in the Journal of Cell Biology report. "Here, we describe a novel function for calpain 2 in the formation of invadopodia and in the invasive abilities of breast cancer cells through the modulation of endogenous c-Src activity. Calpain-deficient breast cancer cells show impaired invadopodia formation that is rescued by expression of a truncated fragment of protein tyrosine...
Source: Women's Health Weekly (2008-06-19)
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