Women's Health Weekly
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Breast Cancer
Data from Johns Hopkins University advance knowledge in breast cancer
July 3rd, 2008
"Our previous studies have shown that HOXB7 mRNA is overexpressed in similar to 50% of invasive breast carcinomas and promotes tumor progression in breast cancer cells grown as xenografts in mice. In silico analysis of published microarray data showed that high levels of HOYB7 predict a poor outcome in HER-2-positive (P = 0.046), but not in HER-2-negative breast cancers (P = 0.94)," investigators in the United States report. "To study the function of HOXB7 in vivo in the context of HER-2 overexpression, we generated mouse mammary tumor virus (MMTV)-Hoxb7 transgenic mice, and then crossed them with MMTV-HER-2/neu transgenic mice. In the mice carrying both Hoxb7 and...
Source: Women's Health Weekly (2008-07-03)
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