Women's Health Weekly
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Breast Cancer
Findings from Shanghai Jiao Tong University provide new insights into breast cancer
July 3rd, 2008
According to recent research from Shanghai, People's Republic of China, "The aim of the present study was to investigate the reversing effect of levistolide A (LA) on P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) in human breast carcinoma Bcap37/MDR1 cells. After chemotherapeutic drugs (adriamycin or vincristine) used alone or in combination with LA, cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazo-lium bromide assay and cell cycle distribution by flow cytometry." "RT-PCR was used to detect MDR1 gene transcription and the Western blot assay was used to assess P-gp expression and the cleavages of poly(ADP-ribose)...
Source: Women's Health Weekly (2008-07-03)
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