Women's Health Weekly
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Breast Cancer
New breast cancer study findings have been reported by scientists at University of Oxford
July 3rd, 2008
According to recent research from Oxford, the United Kingdom, "The 85-kb breast cancer-associated gene BRCA1 is an established tumor suppressor gene, but its regulation is poorly understood. We demonstrate by gene conformation analysis in both human cell lines and mouse mammary tissue that gene loops are imposed on BRCA1 between the promoter, introns, and terminator region." "Significantly, association between the BRCA1 promoter and terminator regions change upon estrogen stimulation and during lactational development. Loop formation is transcription-dependent, suggesting that transcriptional elongation plays an active role in BRCA1 loop formation. We show that the...
Source: Women's Health Weekly (2008-07-03)
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