Women's Health Weekly
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Breast Cancer
New data from S.S. Lum et al illuminate research in breast cancer
July 3rd, 2008
According to a study from Singapore, Singapore, "Sporadic breast cancer in women <40 years is uncommon in Caucasians, in contrast to a much earlier onset in Chinese Asians. However, the molecular determinants for this earlier onset are unclear." "It has been reported that SNP309 in the promoter of MDM2, the negative regulator of p53, affects the onset age of cancers in females. Essentially, the G allele, rather than the T allele, has been suggested to accelerate the age of cancer onset. Hence, we examined if MDM2 and p53 polymorphisms would be determinants of the early onset phenomenon in Chinese women. Our results indicate that the MDM2 SNP309 G allele is more...
Source: Women's Health Weekly (2008-07-03)
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