Women's Health Weekly
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Breast Cancer
Reports outline breast cancer study results from Georgetown University
July 3rd, 2008
According to recent research published in the journal Cancer Research, "Overexpression of the oncogene amplified in breast cancer I (AIBI)/steroid receptor coactivator-3 (SRC-3) induces Mammary tumorigenesis in mice. In breast cancer, high levels of AIBI/SRC-3 and the growth factor receptor HER2/neu predict resistance to endocrine therapy and poor outcome." "However, a mechanistic relationship between AIBI/SRC-3 and HER2/neu in the development of breast cancer has not been shown. Here, we show that deletion of one allele of SRC-3 significantly delays Neu-induced mammary tumor development in mice. Homozygous deletion of SRC-3 in mice completely prevents...
Source: Women's Health Weekly (2008-07-03)
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