Women's Health Weekly
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Breast Cancer
Research on breast cancer detailed by A. Boulay and co-authors
July 3rd, 2008
According to recent research from Basel, Switzerland, "A limited number of receptor tyrosine kinases (e.g., ErbB and fibroblast growth factor receptor families) have been genetically linked to breast cancer development. Here, we investigated the contribution of the Ret receptor tyrosine kinase to breast tumor biology." "Ret was expressed in primary breast tumors and cell lines. In estrogen receptor (ER)a-positive MCF7 and T47D lines, the ligand (glial-derived neurotrophic factor) activated signaling pathways and increased anchorage-independent proliferation in a Ret-dependent manner, showing that Ret signaling is functional in breast tumor cells. Ret expression was...
Source: Women's Health Weekly (2008-07-03)
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