Women's Health Weekly
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Breast Cancer
New breast cancer data have been reported by A. Vazquezmartin and co-authors
July 10th, 2008
According to recent research from Spain, "Discovery of key proliferative and/or survival cascades closely linked to the biological effects of human epidermal growth factor receptor (HER) 1 (erb B-1) and/or HER2 (erb B-2) inhibitors may identify a priori mechanisms responsible for the development of acquired resistance in breast cancer disease. Here, we took advantage of a semiquantitative protein array technology to identify intracellular oncogenic kinases that distinctively correlate with breast cancer cell sensitivity/resistance to the dual-HER1/HER2 tyrosine kinase inhibitor lapatinib (Tykerb (R))." "MCF-7 cells were forced to overexpress HER2 following stable...
Source: Women's Health Weekly (2008-07-10)
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