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Women's Health Weekly

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Breast Cancer



New breast cancer research from University of Turin discussed



July 10th, 2008

"Persistent circadian rhythm of bone turnover in bone metastatic breast cancer suggests greater skeletal retention of bisphosphonates if administered in the night. We assessed differential effects of night vs morning administration of zoledronic acid (ZA) on bone turnover," researchers in Orbassano, Italy report.

"Forty-four breast cancer patients with bone metastases were randomised to receive intravenous ZA (4mg) at 1100 or 2300 hours every 28 days for four times. Urinary concentration N-telopeptide of type-I collagen (NTX) and deoxypyridinolines, and serum C-telopeptide of type-I collagen (CTX), bone alkaline phosphatase (ALP), osteocalcin and Parathyroid hormone...


Source: Women's Health Weekly (2008-07-10)

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