Women's Health Weekly
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Breast Cancer
Study findings from Northwestern University provide new insights into breast cancer
July 10th, 2008
According to a study from the United States, "Fluctuating oxygen levels characterize the microenvironment of many cancers and tumor hypoxia is associated with increased invasion and metastatic potential concomitant with a poor prognosis. Similarly, the expression of lysyl oxidase (LOX) in breast cancer facilitates tumor cell migration and is associated with estrogen receptor negative status and reduced patient survival." "Here we demonstrate that hypoxia/reoxygenation drives poorly invasive breastcancer cells toward a more aggressive phenotype by up-regulating LOX expression and catalytic activity. Specifically, hypoxia markedly increased LOX protein expression;...
Source: Women's Health Weekly (2008-07-10)
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