Women's Health Weekly
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Breast Cancer
Studies from X.W. Chen and co-researchers yield new data on breast cancer
July 17th, 2008
"The contribution of BRCA1 and BRCA2 to familial and non-familial forms of breast cancer has been difficult to accurately estimate because of the myriad of potential genetic and epigenetic mechanisms that can ultimately influence their expression and involvement in cellular activities. As one of these potential mechanisms, we investigated whether allelic imbalance (AI) of BRCA1 or BRCA2 expression was associated with an increased risk of developing breast cancer," scientists in the United States report. "By developing a quantitative approach utilizing allele-specific real-time PCR, we first evaluated AI caused by nonsense-mediated mRNA decay in patients with frameshift...
Source: Women's Health Weekly (2008-07-17)
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