Women's Health Weekly
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Cervical Cancer
Research from J. Lee and co-authors in the area of cervical cancer published
July 17th, 2008
According to a study from South Korea, "Our study was designed to demonstrate that DICKKOPF-1 (DKX-1), encoding a secreted Writ antagonist, is transcriptionally repressed by epigenetic alterations in cervical carcinoma cell lines. Methylation-specific PCR for 8 human cervical cancer cell lines and bisulfite sequencing for 4 cell lines exhibiting significant difference in methylation levels were used to determine CpG-island methylation status at the 5'-end region of DKX-1." "The chromatin immunoprecipitation assay was performed to determine whether HeLa cells recruit histone deacetylation for DKX-1 silencing. Two out of eight cervical cancer cell lines examined were...
Source: Women's Health Weekly (2008-07-17)
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