Women's Health Weekly
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Ductal Carcinoma
Data from University of Memphis advance knowledge in ductal carcinoma
July 17th, 2008
"CYP1B1 and CYP19 ( aromatase) have been shown to be expressed in breast tumors. Both enzymes are efficient estrogen hydroxylases, indicating the potential for overlapping substrate and inhibitor specificity," scientists writing in the journal Drug Metabolism and Disposition report. "We measured the inhibition properties of aromatase inhibitors (AIs) against CYP1B1-catalyzed hydroxylation of 17 beta-estradiol (E2) to determine whether CYP1B1 affects the disposition of AIs. In addition, we estimated the frequency of coexpression of these enzymes in breast tumor epithelium. Immunohistochemical analyses of CYP19 and CYP1B1 in a panel of 29 cases of invasive ductal...
Source: Women's Health Weekly (2008-07-17)
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