Women's Health Weekly
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Endometrial Cancer
New endometrial cancer study findings recently were published by D. Llobet and co-researchers
July 17th, 2008
"Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising antineoplastic agent because of its ability to selectively kill tumoral cells. However, some cancer cells are resistant to TRAIL-induced apoptosis," scientists in Spain report. "We have previously demonstrated that in endometrial carcinoma cells such resistance is caused by elevated FLICE-inhibitory protein (FLIP) levels. The present study focuses on the mechanisms by which FLIP could be modulated to sensitize endometrial carcinoma cells to TRAIL-induced apoptosis. We find that inhibition of casein kinase (CK2) sensitizes endometrial carcinoma cells to TRAIL-and Fas-induced...
Source: Women's Health Weekly (2008-07-17)
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