Women's Health Weekly
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Life Sciences
Studies from Johns Hopkins University in the area of life sciences described
July 17th, 2008
According to recent research from the United States, "Chemical biology studies, exemplified by metabolic glycoengineering experiments that employ short chain fatty acid (SCFA)-hexosamine monosaccharide hybrid molecules, often suffer from off-target effects. Here we demonstrate that systematic structure-activity relationship (SAR) studies can deconvolute multiple biological activities of SCFA-hexosamine analogues by demonstrating that triacylated monosacch a rides, including both n-butyrate- and acetate-modified ManNAc analogues, had dramatically different activities depending on whether the free hydroxyl group was at the C1 or C6 position." "The Cl-OH (hemiacetal)...
Source: Women's Health Weekly (2008-07-17)
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