Women's Health Weekly
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Breast Cancer
New breast cancer data have been reported by scientists at University of Nottingham
July 24th, 2008
"Compounds within the 2-(4-aminophenyl)benzothiazole class represent extremely potent and selective experimental antitumour agents. The lysylamide prodrug of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole is undergoing phase I clinical evaluation," researchers in Nottingham, the United Kingdom report. "Extensive studies to elucidate mechanisms underlying the stark selectivity demonstrated potent cytosolic AhR ligand binding and cytochrome P450 1A1-catalysed bioactivation. Two human derived breast cell lines, initially exquisitely sensitive to this class of agent (GI(50) < 5 nM) have been derived displaying acquired resistance to...
Source: Women's Health Weekly (2008-07-24)
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