Women's Health Weekly
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Breast Cancer
New breast cancer data have been reported by scientists at University of Wisconsin
July 24th, 2008
"Tryprostatin A is an inhibitor of breast cancer resistance protein, consequently a series of structure-activity studies on the cell cycle inhibitory effects of tryprostatin A analogues as potential antitumor antimitotic agents have been carried out. These analogues were assayed for their growth inhibition properties and their ability to perturb the cell cycle in tsFT210 cells," investigators in the United States report. "SAR studies resulted in the identification of the essential structural features required for cytotoxic activity. The absolute configuration L-Tyr-L-pro in the diketopiperazine ring along with the presence of the 6-methoxy substituent on the indole...
Source: Women's Health Weekly (2008-07-24)
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