Women's Health Weekly
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Breast Cancer
New breast cancer study findings recently were published by E. Arriola and co-researchers
July 24th, 2008
"HER2 and TOP2A are targets for the therapeutic agents trastuzumab and anthracyclines and are frequently amplified in breast cancers. The aims of this study were to provide a detailed molecular genetic analysis of the 17q12-q21 amplicon in breast cancers harbouring HER2/TOP2A co-amplification and to investigate additional recurrent co-amplifications in HER2/TOP2A- co-amplified cancers," scientists in London, the United Kingdom report. "In total, 15 breast cancers with HER2 amplification, 10 of which also harboured TOP2A amplification, as defined by chromogenic in situ hybridisation, and 6 breast cancer cell lines known to be amplified for HER2 were subjected to...
Source: Women's Health Weekly (2008-07-24)
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