Ovarian Cancer

Study data from University of Gdansk provide new insights into ovarian cancer

Published in Women's Health Weekly, July 24th, 2008

"Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta 1 genes was examined in ovarian tissue specimens including 19 normal ovaries, 20 benign tumors, 7 borderline tumors, 44 cancers and 8 Krukenberg tumors. mRNA and protein levels were evaluated by semi-quantitative RT-PCR and Western-blotting methods, respectively," scientists writing in the journal Clinical Biochemistry report.

"A statistically significant decrease of HtrA1 and HtrA3 expression in ovarian tumors comparing to normal tissues was observed. A dramatic decrease of HtrA3 mRNA and protein levels in all tumor tissue groups, and a loss of HtrA3 protein in 30% malignant tumors were found. A significant...

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Source: Women's Health Weekly (2008-07-24)

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