Women's Health Weekly
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Breast Cancer
Research from Michigan State University broadens understanding of breast cancer
July 24th, 2008
According to recent research from the United States, "Cancer associated fibroblasts (CAFs) are believed to promote tumor growth and progression. Our objective was to measure the effect of TGF-beta 1 on fibroblasts isolated from invasive breast cancer patients." "Fibroblasts were isolated from tissue obtained at surgery from patients with invasive breast cancer (CAF; n = 28) or normal reduction mammoplasty patients (normal; n = 10). Myofibroblast activation was measured by counting cells immunostained for smooth muscle alpha actin (ACTA2) in cultures +/- TGF-beta 1. Conditioned media (CM) was collected for invasion assays and RNA was isolated from cultures incubated in...
Source: Women's Health Weekly (2008-07-24)
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