Women's Health Weekly
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Breast Cancer
Research from University of Utah, Medical Department in the area of breast cancer published
July 24th, 2008
"Identifying mutations in the TP53 gene is important for cancer prognosis, predicting response to therapy, and determining genetic risk. We have developed a high-throughput scanning assay with automatic calling to detect TP53 mutations in DNA from fresh frozen (FF) and formalin,fixed paraffin-embedded (FFPE) tissues," investigators in the United States report. "The coding region of the TP53 gene (exons 2-11) was PCR amplified from breast cancer samples and scanned by high-resolution fluorescent melting curve analyses using a 384 well format in the LightCycler 480 instrument. Mutations were confirmed by direct sequencing. Sensitivity and specificity of scanning and...
Source: Women's Health Weekly (2008-07-24)
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