Women's Health Weekly
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Angiogenesis
New findings from University of London, Medical Department in the area of angiogenesis described
July 24th, 2008
According to recent research published in the Journal of Nuclear Medicine, "The integrin alpha(v)beta(3) receptor is upregulated on tumor cells and endothelium and plays important roles in angiogenesis and metastasis. Arg-Gly-Asp (RGD) peptide ligands have high affinity for these integrins and can be radiolabeled for PET :imaging of angiogenesis or tumor development." "We have assessed the safety, stability, and tumor distribution kinetics of a novel radiolabeled RGD-based integrin peptide-polymer conjugate, AH111585, and its feasibility to detect tumors in metastatic breast cancer patients using PET. The biodistribution of (18)FAH111585 was assessed in 18 tumor...
Source: Women's Health Weekly (2008-07-24)
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