Women's Health Weekly
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Breast Cancer
Data from D. Loussouarn et al provide new insights into breast cancer
July 31st, 2008
According to recent research published in the British Journal of Cancer, "Carcinoma cells lack syndecan-1 expression when they are transiting from an epithelial to a less-differentiated mesenchymal phenotype (epithelial-mesenchymal transition, EMT). Furthermore, a shift of syndecan-1 expression from malignant epithelial cells to reactive stromal cells has also been observed during progression of many carcinomas." "Finally, epithelial and/or stromal syndecan-1 expression is of prognostic value in many carcinomas. Because recent results are contradictory in breast carcinomas, we have re-evaluated the prognostic significance of syndecan-1 expression in a cohort of...
Source: Women's Health Weekly (2008-07-31)
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