Women's Health Weekly
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Breast Cancer
Research results from J.J. Northey and colleagues update understanding of breast cancer
July 31st, 2008
According to a study from Montreal, Canada, "Cooperation between the Neu/ErbB-2 and transforming growth factor beta (TGF-beta) signaling pathways enhances the invasive and metastatic capabilities of breast cancer cells; however, the underlying mechanisms mediating this synergy have yet to be fully explained. We demonstrate that TGF-beta induces the migration and invasion of mammary tumor explants expressing an activated Neu/ErbB-2 receptor, which requires signaling from autophosphorylation sites located in the C terminus." "A systematic analysis of mammary tumor explants expressing Neu/ErbB-2 add-back receptors that couple to distinct signaling molecules has mapped the...
Source: Women's Health Weekly (2008-07-31)
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