Women's Health Weekly
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Breast Cancer
Study results from S. Hua and colleagues update understanding of breast cancer
July 31st, 2008
"We demonstrate an integrated approach to the study of a transcriptional regulatory cascade involved in the progression of breast cancer and we identify a protein associated with disease progression. Using chromatin immunoprecipitation and genome tiling arrays, whole genome mapping of transcription factor-binding sites was combined with gene expression profiling to identify genes involved in the proliferative response to estrogen (E2)," researchers in the United States report. "Using RNA interference, selected ER alpha and c-MYC gene targets were knocked down to identify mediators of E2-stimulated cell proliferation. Tissue microarray screening revealed that high...
Source: Women's Health Weekly (2008-07-31)
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