Women's Health Weekly
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Carcinogenesis
Scientists at University of Tennessee, Medical Department publish research in carcinogenesis
July 31st, 2008
"To understand carcinogenesis of human breast epithelial cells induced by chronic exposure to environmental pollutants, we studied biological and molecular changes in progression of cellular carcinogenesis induced by accumulated exposures to the potent environmental carcinogen benzo[a]pyrene (B[a]P). Increasing exposures of human breast epithelial MCF10A cells to B[a]P at picomolar concentrations resulted in cellular transformation from a noncancerous stage to precancerous substages, in which cells acquired the cancerous abilities of a reduced dependence on growth factors, anchorage-in dependent growth, and disruption in acini formation on reconstituted basement membranes," investigators...
Source: Women's Health Weekly (2008-07-31)
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