Women's Health Weekly
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Life Sciences
Investigators at National Institutes of Health have published new data on life sciences
July 31st, 2008
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "Previous work identified the Rap1 GTPase-activating protein Sipal as a germ-line-encoded metastasis modifier. The bromodomain protein Brd4 physically interacts with and modulates the enzymatic activity of Sipal." "In vitro analysis of a highly metastatic mouse mammary tumor cell line ectopically expressing Brd4 demonstrates significant reduction of invasiveness without altering intrinsic growth rate. However, a dramatic reduction of tumor growth and pulmonary metastasis was observed after s.c. implantation into mice, implying...
Source: Women's Health Weekly (2008-07-31)
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