Women's Health Weekly
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Life Sciences
Researchers from Medical University of South Carolina publish new studies and findings in the area of life sciences
July 31st, 2008
"The chemotherapeutic agent cisplatin is widely used in treatment of solid tumors. In breast cancer cells, cisplatin produces early and marked changes in cell morphology and the actin cytoskeleton," scientists in the United States report. "These changes manifest as loss of lamellipodia/filopodia and appearance of membrane ruffles. Furthermore, cisplatin induces dephosphorylation of the actin-binding protein ezrin, and its relocation from membrane protrusions to the cytosol. Because cisplatin activates acid sphingomyelinase (ASMase), we investigate here the role of the ASMase/ceramide (Cer) pathway in mediating these morphological changes. We. nd that cisplatin induces a...
Source: Women's Health Weekly (2008-07-31)
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